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Literature summary extracted from
- Biochemical basis of APOBEC3 deoxycytidine deaminase activity on diverse DNA substrates (2018), ACS Infect. Dis., 4, 224-238 .
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.B9 | cytosine in single-stranded DNA + H2O | Homo sapiens | the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state | uracil in single-stranded DNA + NH3 | - |
? |  |
| 3.5.4.B9 | cytosine in single-stranded viral DNA + H2O | Homo sapiens | the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state | uracil in single-stranded viral DNA + NH3 | - |
? | |
| 3.5.4.38 | cytosine in single-stranded DNA + H2O | Homo sapiens | the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state | uracil in single-stranded DNA + NH3 | - |
? | |
| 3.5.4.38 | cytosine in single-stranded DNA + H2O | Homo sapiens | the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state in DNA | uracil in single-stranded DNA + NH3 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.B9 | Homo sapiens | Q9HC16 | - |
- |
| 3.5.4.38 | Homo sapiens | P31941 | - |
- |
| 3.5.4.38 | Homo sapiens | Q6NTF7 | - |
- |
| 3.5.4.38 | Homo sapiens | Q8IUX4 | - |
- |
| 3.5.4.38 | Homo sapiens | Q96AK3 | - |
- |
| 3.5.4.38 | Homo sapiens | Q9HC16 | - |
- |
| 3.5.4.38 | Homo sapiens | Q9NRW3 | - |
- |
| 3.5.4.38 | Homo sapiens | Q9UH17 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.B9 | cytosine in single-stranded DNA + H2O | - |
Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
| 3.5.4.B9 | cytosine in single-stranded DNA + H2O | the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state | Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
| 3.5.4.B9 | cytosine in single-stranded viral DNA + H2O | - |
Homo sapiens | uracil in single-stranded viral DNA + NH3 | - |
? | |
| 3.5.4.B9 | cytosine in single-stranded viral DNA + H2O | the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state | Homo sapiens | uracil in single-stranded viral DNA + NH3 | - |
? | |
| 3.5.4.38 | cytosine in single-stranded DNA + H2O | - |
Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
| 3.5.4.38 | cytosine in single-stranded DNA + H2O | the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state | Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
| 3.5.4.38 | cytosine in single-stranded DNA + H2O | the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state in DNA | Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.4.B9 | APOBEC3G | - |
Homo sapiens |
| 3.5.4.38 | APOBEC3A | - |
Homo sapiens |
| 3.5.4.38 | APOBEC3B | - |
Homo sapiens |
| 3.5.4.38 | APOBEC3C | - |
Homo sapiens |
| 3.5.4.38 | APOBEC3D | - |
Homo sapiens |
| 3.5.4.38 | APOBEC3F | - |
Homo sapiens |
| 3.5.4.38 | APOBEC3G | - |
Homo sapiens |
| 3.5.4.38 | APOBEC3H | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.5.4.B9 | metabolism | the APOBEC3 family has many roles, such as restricting endogenous and exogenous retrovirus replication and retrotransposon insertion events and reducing DNA-induced inflammation | Homo sapiens |
| 3.5.4.38 | metabolism | the APOBEC3 family has many roles, such as restricting endogenous and exogenous retrovirus replication and retrotransposon insertion events and reducing DNA-induced inflammation | Homo sapiens |
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Release 2023.1 (January 2023)
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